The Peptide Synthesis Charges (FY 2012)

Policy: Synthesis of crude peptides is "as is". We cannot guarantee a certain level of purity or yield of crude peptide because this is not predictable. However, if you order HPLC purification with the 0.1 mmol synthesis, if we cannot deliver at least one mg of product that is at least 80% peptide pure by analytical HPLC and MALDI-TOF analysis, then you do not have to pay. This only applies to the 0.1 mmol scale synthesis. The greater than 25 amino acid syntheses are technically more challenging and will require the payment of the minimum synthesis charge even in the event of synthesis failure. In the event of instrument malfunction or operator error, resynthesis will be performed free of charge.

Please note: Outside non-profit organizations will be charged a 50% surcharge over these prices.

Synthetic services:

0.025 mmole scale (Crude Only)No longer than 25 amino acids (see below)RU (per AA)
Synthesis up to 25 Amino Acids includes cleavage of all resin and analysis $10 ($100 minimum)
Outside Users $15 ($150 minimum)
0.05 mmole scaleNo longer than 25 amino acids (see below)RU
Synthesis up to 25 Amino Acids includes cleavage of all resin and analysis $20 ($100 minimum)
Outside Users $30 ($150 minimum)
0.1 mmole scaleNo longer than 25 amino acids (see below)RU
Synthesis up to 25 Amino Acids includes cleavage of all resin and analysis $26* ($120 minimum)
Outside Users $39* ($180 minimum)

Other charges (special modifications, etc.) according to .1 mmol scale synthesis chart.

We can also accommodate large scale manual syntheses. Please inquire for details and pricing.

We are not limited to the modifications on this list. We can accommodate virtually any available modification provided it is FMOC protected and suitably side chain protected. Additionally, many modifications to primary amines (typically N-terminus, lysine side chain, ornithine side chain and amino hexanoic acid) are also possible. Please inquire for suitability and pricing. Contact Mouli Chandramouli and Henry Zebroski (212)327-8867 for more information.

Special custom services:

HPLC Purification and Desalting Up to 100 mg of crude peptide applied per run. Includes analysis of relevant fractions $244 and up
Outside $366 and up
Additional Cleavages, if resin is available (includes crude QC Analysis) up to 400 mg of resin $180
Outside $270
QC Reanalysis Only (Analytical HPLC and MALDI-TOF MS) Analysis $30
Outside $45

Small scale library synthesis on the Intavis

Scale10 μmole (8-12 mg)* (Wang or amide C-terminus)
Full plate (up to 96 peptides) $3375/$5063-ouside users
Half plate (up to 48 peptides) $2673/$4010-outside users
Quarter plate (up to 24 peptides) $2268/$3402-outside users
Membrane array (up to 384 peptides): $499/$748-outside (scale not applicable)

Special amino acids, dye labeling, stable isotopes, biotinylation and other modifications are available at extra charge. Please inquire.

* quantities are approximate and not guaranteed. The final yield will depend on the sequence and degree of difficulty of synthesis.

Large Scale library synthesis on the Symphony is also available. Prices vary according to peptide length, number and quantity. Prices are significantly lower than for custom peptide synthesis. Please inquire for consultation and a customized quote. Contact Mouli Chandramouli and Henry Zebroski (212)327-8867 for more information.